who we are
About the lab
The Systems Biomedicine Lab is part of the Mina and Everard Goodman Faculty of Life Sciences at Bar-Ilan University, Ramat Gan, Israel.
The lab is led by Prof. Sol Efroni.
What we do
We study two sources of biological data: T cells and tumor cells. Each of us carries millions of distinct T cell receptors, and together they record what the immune system has met and how it responded. We sequence that record, read tumor transcriptomes beside it, and build computational methods that turn these data into biology and, we hope, into better medicine.
How we work
We produce our own data
We generate high-throughput T cell repertoire and transcriptome data from patients and model systems. With Dr. Assaf Rotem and Dave Weitz's lab we set up droplet microfluidics for single-cell transcriptomics.
We build the methods to read it
Machine learning, network and pathway analysis, and models of cell behavior. What the computation points to, we test at the bench.
We share what we make
Our software is open, and our datasets are published in Scientific Data. See Tools & data.
We measure ourselves against others
We take part in community benchmarks of repertoire and deconvolution methods. Our solution won the AIRR-ML 2025 challenge.
Where the lab comes from
The lab grew out of executable biology. Sol Efroni trained across physics, mathematics and biology, and did his PhD at the Weizmann Institute of Science with David Harel and Irun Cohen, modeling thymocyte development as an executable statechart system. That view of the immune system as a computing system still shapes how we read repertoires.
Find us
The Systems Biomedicine LabMina and Everard Goodman Faculty of Life Sciences
Building 206, Room C863
Bar-Ilan University
Ramat Gan 5290002, Israel
Join us
We welcome MSc and PhD students and postdocs who want to work where biology meets computation. Backgrounds in biology, computer science, physics, mathematics or engineering all fit.
Write to us through the contact form and choose "Joining the lab".